Biochemical and Structural Basis of Sialic acid Utilization by Gut Microbes

Author(s)

A. Bell, E. Severi, C.D. Owen, D. Latousakis & N. Juge

Sources

Journal Biological Chemistry, 2023, 102089 https://doi.org/10.1016/j.jbc.2023.102989

The human gastrointestinal (GI) tract harbours diverse microbial communities collectively known as the gut microbiota, which profoundly impact human health and disease. The repartition and availability of sialic acid derivatives in the gut significantly affect the modulation of gut microbes and host susceptibility to infection and inflammation. Although N-acetylneuraminic acid (Neu5Ac) is the main form of sialic acids in humans, the sialic acid family regroups more than 50 structurally and chemically distinct modified derivatives.
juge.png
In the GI tract, sialic acids are found in the terminal location of mucin glycan chains constituting the mucus layer but also come from human milk oligosaccharides in the infant’s gut or meat-based foods in adults. The repartition of sialic acid in the GI tract influences the gut microbiota composition and pathogen colonization. In this review, the authors provide an update on the mechanisms underpinning sialic acid utilization by gut microbes, focusing on sialidases, transporters, and metabolic enzymes.

Latest news

 The carbohydrate 3D structure-prediction tools (builders) at GLYCAM-Web (glycam.org) are widely used for generating experimentally-consistent...

Glycosylation, the key reaction in synthetic glycochemistry, remains entirely unpredictable due to its complex mechanism...

The ‘taste of sweetness’ is one of the most iconic and universally recognised human sensory...

recognize sialic acid residues on cell surfaces. Pathogens and tumor cells exploit Siglecs to evade...