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A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors

In 2024, several human infections with highly pathogenic clade 2.3.4.4b bovine influenza H5N1 viruses in...

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Protein-Carbohydrate Interfaces. PDB depositions: November_2024

DIONYSUS is a database of protein-carbohydrate interfaces annotated according to proteins and carbohydrates’ structural, chemical...

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Fucosylation of glycoproteins and glycolipids: opposing roles in cholera intoxication

Cholera toxin (CT) is the etiological agent of cholera. The authors report that multiple classes...

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Efficient conversion of hemicellulose into high-value product and electric power by enzyme-engineered bacterial consortia

As an abundant agricultural and forestry biomass resource, hemicelluloses are hard to effectively degrade and...

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Contrasting macroevolutionary patterns in the human N-glycosylation pathway

Based on coding mutations and splicing variants, post-translational modifications add a final layer to protein...

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Protein-Carbohydrate Interfaces. PDB depositions: October_2024

DIONYSUS is a database of protein-carbohydrate interfaces annotated according to proteins and carbohydrates’ structural, chemical...

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Glycoprotein Analysis

New Developments in Mass Spectrometry. Overview of Glycosylation Studies of SARS-CoV-2 1 Lauren E. Pepi,...

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NMR investigations of glycan conformation, dynamics, and interactions  NMR investigations of glycan conformation, dynamics, and interactions

Glycans are ubiquitous in nature, decorating our cells and serving as the initial points of...

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Restoring protein glycosylation with GlycoShape

Despite ground-breaking innovations in experimental structural biology and protein structure prediction techniques, capturing the structure...

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Comparative Assessment of Water Models in Protein−Glycan Interaction: Insights from Alchemical Free Energy Calculations and Molecular Dynamics Simulations

Accurate computational simulations of protein−glycan dynamics are crucial, critically relying on the appropriate parameters, including...

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Unleashing the Power of Domino Reactions on Carbohydrates: State of the Art

The intricate nature of carbohydrate structures has led the scientific community to seek efficient protocols...

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The future of integrated structural biology

Instruct-ERIC, ”the European Research Infrastructure Consortium for Structural biology research”, is a pan-European distributed research...

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Protein-Carbohydrate Interfaces. PDB depositions: September_2024

DIONYSUS is a database of protein-carbohydrate interfaces annotated according to proteins and carbohydrates’ structural, chemical...

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MolPlay: Democratizing Interactive Molecular Simulations and Analyses with a Portable, Turnkey Platform

Computer-based tools for visualizing and manipulating molecular structures in real-time hold immense potential for accelerating...

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Synthesis and screening of a library of LewisX deoxyfluoro-analogues reveals differential recognition by glycan-binding partners

Glycan-mediated interactions are crucial in biology and medicine, influencing signalling, immune responses, and disease pathogenesis....

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