Search
Close this search box.

Spike-heparan sulfate interactions in…

Author(s)

F.L. Kearns, D.R. Sandoval, L. Casalino, T.M. Clausen, M.A. Rosenfeld, C.B. Spliid, R.E. Amaro & J.D. Esko

Sources

Spike-heparan sulfate interactions in SARS-CoV-2 infection Current Opinion in Structural Biology 2022, 76:102439

All cells are surrounded by a glycocalyx composed of various types of glycoconjugates, glycoproteins, glycosphingolipids, and proteoglycans which are exploited by many viruses as attachment factors and receptors for infections. One of the major components of the cellular glycocalyx participates in the infection of SARS-CoV-2, facilitating the so-called open conformation of the spike protein, which is required for binding to angiotensin-converting enzyme 2 (ACE2).
sars-hspg.jpg
In this timely review, the authors decipher the close coordination between host cell heparan sulfate and asparagine-linked glycans on the viral spike protein that enables binding, leading to subsequent infection.

Latest news

In biological systems, vascular networks play a pivotal role in regulating the chemical compositions of...

Amylose, a linear polymer comprised of α-1,4-linked glucopyranose units, is renowned for its propensity to...

Algae play an important ecological role as oxygen producers and carbon sequesters and are the...

Streptococcus gordonii is a Gram-positive bacterial species that typically colonizes the human oral cavity, but...