Glycomimetics against Multi-Drug Resistant Pathogens

Author(s)

R. Bermeo

Sources

http://glycopedia.eu/IMG/pdf/glycomimetics_against_multi-drug_resistant_pathogens.pdf

The collection of glycopedia virtual chapters has been extended with a new contribution

Multi-drug resistant (MDR) pathogens such as Burkholderia cenocepacia have become a hazard in the context of healthcare-associated infections, especially for patients admitted with compromising or aggravating conditions. Like other opportunistic Gram-negative bacteria, this pathogen establishes virulence and biofilms through lectin-mediated adhesion. Glycans and glycomimetics have become devices of choice to antagonize or disrupt such interactions. The article provides an overview of this topic, highlighting anti-microbial resistance (AMR), anti-adhesion therapy (AAT), carbohydrate-lectin interactions, and glycomimetics as therapeutic agents. An example highlights the case of MDR lung pathogens, in particular Burkholderia cenocepacia.

antiadhesion.png

Latest news

Cellulose, the most abundant polysaccharide on earth, composing plant cell walls, is synthesized by coordinated...

Osteoarthritis (OA) is a degenerative disease affecting cartilage, synovium, and bone, and it is a...

Tools for structural lectinomics: From structures to lectomes Lectins are ubiquitous proteins that interact with...