Structure and Engineering of Tandem Repeat Lectins

Author(s)

S. Notova, F. Bonnardel, F. Lisacek, A. Varrot & A. Imberty

Sources

Structure and engineering of tandem repeat lectins Current Opinion Structural Biology, 2020, 62; 39-47

Through their ability to bind complex glycoconjugates, lectins have unique specificity and potential for biomedical and biotechnological applications. In particular, lectins with short repeated peptides forming carbohydrate-binding domains are not only of high interest for understanding protein evolution but can also be used as a scaffold for engineering novel receptors.
capture-25.png
Synthetic glycobiology now provides the tools for engineering the specificity of lectins as well as their structure, multivalency and topologies. This review focuses on the structure and diversity of two families of tandem-repeat lectins, that is, β-trefoils and β-propellers, demonstrated as the most promising scaffold for engineering novel lectins.

Latest news

DIONYSUS is a database of protein-carbohydrate interfaces annotated according to proteins and carbohydrates’ structural, chemical...

Understanding the molecular mechanisms that drive and modulate host-pathogen interactions is essential for developing effective...

Crystalline polysaccharides are abundant and can be transformed into highly functional materials. However, the molecular...

The authors have developed a research strategy, called CryoSeek, to identify uncharacterized bio-entities from natural...