Multi-drug resistant (MDR) pathogens such as Burkholderia cenocepacia have become a hazard in the context of healthcare-associated infections, especially for patients admitted with compromising or aggravating conditions. Like other opportunistic Gram-negative bacteria, this pathogen establishes virulence and biofilms through lectin-mediated adhesion.
Glycans and glycomimetics have become devices of choice to antagonize or disrupt such interactions. We provide an overview of this topic, with spotlights on anti-microbial resistance (AMR), anti-adhesion therapy (AAT), carbohydrate-lectin interactions, and glycomimetics as therapeutic agents.
Furthermore, we focus on the case of MDR lung pathogens, in particular B. cenocepacia. We provide a description of its position amongst other pathogens and highlight the Burkholderia cenocepacia lectin (BC2L) family and the potential of targeting this pathogen with glycomimetics directed to the superlectin BC2L-C.
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