Search
Close this search box.

Outer Membrane Utilisomes Mediate Glycan Uptake in Gut Bacteroidetes

Author(s)

J.B.R White, A. Silale, M. Feasey, T. Heunis, Y. Zhu, H. Zheng, A. Gajbhiye, S. Firbank, Arnaud Baslé, M. Trost, D.N Bolam, B. van den Berg & N.A Ranson

Sources

Nature. 2023;618(7965):583-589. doi 10.1038/s41586-023-06146-w.

Bacteroidetes are abundant members of the human microbiota, utilizing a myriad of diet- and host-derived glycans in the distal gut1. Glycan uptake across the bacterial outer membrane of these bacteria is mediated by SusCD protein complexes, comprising a membrane-embedded barrel and a lipoprotein lid, which is thought to open and close to facilitate substrate binding and transport. However, surface-exposed glycan-binding proteins and glycoside hydrolases also play critical roles in capturing, processing, and transporting large glycan chains. The interactions between these components in the outer membrane are poorly understood, despite being crucial for nutrient acquisition by our colonic microbiota. Here we show that for both the levan and dextran utilization systems of Bacteroides thetaiotaomicron, the additional outer membrane components assemble on the core SusCD
bacteroides.png

Latest news

Plastic production reached 400 million tons in 2022, with packaging and single-use plastics accounting for...

Glycans constitute the most complicated post-translational modification, modulating protein activity in health and disease. However,...

The introduction of AlphaFold 2 has sparked a revolution in the modelling of protein structure...

Understanding how carbohydrates regulate proteins in physiological and pathological processes provides opportunities to address key...