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Recent Advances in Electron Microscopy of Carbohydrate Nanoparticles


Y. Ogawa & J-L Putaux


Front. Chem., 15 February 2022 |

Carbohydrate nanoparticles, both naturally derived and synthetic ones, have attracted scientific and industrial attention as high-performance renewable building blocks of functional materials. Electron microscopy (EM) has played a central role in investigations of their morphology and molecular structure, although the intrinsic radiation sensitivity of carbohydrate crystals has often hindered the in-depth characterization with EM techniques.
This contribution reviews the recent advances in the electron microscopy of carbohydrate nanoparticles. In particular, we highlight the recent efforts made to understand the three-dimensional shape and structural heterogeneity of nanoparticles using low-dose electron tomography and electron diffraction techniques coupled with cryogenic transmission electron microscopy.

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