Search
Close this search box.

Total Synthesis of Polysaccharides by Automated Glycan Assembly

Author(s)

Joseph A. A., Pardo-Vargas A. & Seeberger, P.H.

Sources

J. Am. Chem. Soc. 2020, 142, 8561−8564 https://dx.doi.org/10.1021/jacs.0c00751J

Polysaccharide isolation provides heterogeneous mixtures, while heroic efforts were required to complete chemical and/or enzymatic syntheses of polysaccharides as long 92-mers. The authors of the article show that automated glycan assembly (AGA) enables access to a 100-mer polysaccharide via a 201-step synthesis within 188 h. Convergent block coupling of 30- and 31-mer oligosaccharide fragments, prepared by AGA, yielded a multiple-branched 151-mer polymannoside. Quick access to polysaccharides provides the basis for future material science applications of carbohydrates.
peter.png
Such an achievement paves the way to a better understanding of of structures and functions of polysaccharides and other complex carbohydrates.

Latest news

In biological systems, vascular networks play a pivotal role in regulating the chemical compositions of...

Amylose, a linear polymer comprised of α-1,4-linked glucopyranose units, is renowned for its propensity to...

Algae play an important ecological role as oxygen producers and carbon sequesters and are the...

Streptococcus gordonii is a Gram-positive bacterial species that typically colonizes the human oral cavity, but...