Search
Close this search box.

Analysis and Validation of Overall N-glycan Conformation in Privateer

Author(s)

J.S. Dialpuri, H. Bagdonas, M. Atanasova, L.C. Schofield, M.L. Hekkelman, R.P. Joosten & J. Agirrea

Sources

Acta Cryst D, Acta Cryst. (2023). D79, 462–472 https://doi.org/10.1107/S2059798323003510

The oligosaccharides in N-glycosylation provide key structural and functional contributions to a glycoprotein. These contributions are dependent on the composition and overall conformation of the glycans. The Privateer software allows structural biologists to evaluate and improve the atomic structures of carbohydrates, including N-glycans; this software has recently been extended to check glycan composition through the use of glycomics data. The present version of Privateer broadens the scope of the software to analyse and validate the overall conformation of N-glycans is presented, focusing on a newly compiled set of glycosidic linkage torsional preferences harvested from a curated set of glycoprotein models.
privateer-2.png

Latest news

The role of glycosaminoglycans (GAGs) in modulating bone morphogenetic protein (BMP) signaling is a relatively...

Glycans, due to their variable compositions and highly dynamic conformations, significantly enhance the diversity of...

Advances in simulation, combined with technological developments in high-performance computing, have made it possible to...

Antimicrobial resistance (AMR) is one of the most critical threats to global public health in...