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Anti-glycan monoclonal antibodies: Basic research and clinical applications

Author(s)

K.M. Gillmann, J. S. Temme, S. Marglous, C.E. Brown & J. C. Gildersleeve

Sources

Current Opinion in Chemical Biology 2023, 74:102281 https://doi.org/10.1016/j.cbpa.2023.102281

Anti-glycan monoclonal antibodies have essential applications in human health and basic research. Therapeutic antibodies that recognize cancer- or pathogen-associated glycans have been investigated in numerous clinical trials, resulting in two FDA-approved biopharmaceuticals. Anti-glycan antibodies are also utilized to diagnose, prognosticate, and monitor disease progression, as well as to study the biological roles and expression of glycans.
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High-quality anti-glycan mAbs are still in limited supply, highlighting the need for new technologies for anti-glycan antibody discovery. This review discusses anti-glycan monoclonal antibodies with applications to basic research, diagnostics, and therapeutics, focusing on recent advances in mAbs targeting cancer- and infectious disease-associated glycans.
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