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Automated solution-phase multiplicative synthesis of complex glycans up to a 1,080-mer

Author(s)

Wenlong Yao, De-Cai Xiong, Yun Yang, Chunmei Geng, Zisen Cong, Feifei Li, Bo-Han Li, Xianjin Qin, Li-Na Wang, Wan-Ying Xue, Nengfu Yu, Hanyu Zhang, Xia Wu, Miao Liu & Xin-Shan Ye

Sources

Automated solution-phase multiplicative synthesis of complex glycans up to a 1,080-mer Nature Synthesis, 2022 https://doi.org/10.1038/s44160-022-00171-9

The article reports an automated solution-phase multiplicative synthesis of complex glycans enabled by preactivation-based, multi-component, one-pot glycosylation and continuous multiplying amplification. This was achieved by making a dual-mode automated solution-phase glycan synthesizer. Using this synthesizer, a library of oligosaccharides covering various glycoforms and glycosidic linkages was assembled rapidly, either in a general promoter-activation mode or light-induced-activation mode. The automated synthesis of a fully protected fondaparinux pentasaccharide (an anticoagulant) was realized on the gram scale.
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Furthermore, automated ten-component tandem reactions were performed, allowing the assembly of arabinans up to a 1,080-mer using this automated multiplicative synthesis strategy.

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