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Glycomimetics against Multi-Drug Resistant Pathogens

Author(s)

R. Bermeo

Sources

http://glycopedia.eu/IMG/pdf/glycomimetics_against_multi-drug_resistant_pathogens.pdf

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Multi-drug resistant (MDR) pathogens such as Burkholderia cenocepacia have become a hazard in the context of healthcare-associated infections, especially for patients admitted with compromising or aggravating conditions. Like other opportunistic Gram-negative bacteria, this pathogen establishes virulence and biofilms through lectin-mediated adhesion. Glycans and glycomimetics have become devices of choice to antagonize or disrupt such interactions. The article provides an overview of this topic, highlighting anti-microbial resistance (AMR), anti-adhesion therapy (AAT), carbohydrate-lectin interactions, and glycomimetics as therapeutic agents. An example highlights the case of MDR lung pathogens, in particular Burkholderia cenocepacia.

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