Close this search box.

Glycomimetics against Multi-Drug Resistant Pathogens


R. Bermeo


The collection of glycopedia virtual chapters has been extended with a new contribution

Multi-drug resistant (MDR) pathogens such as Burkholderia cenocepacia have become a hazard in the context of healthcare-associated infections, especially for patients admitted with compromising or aggravating conditions. Like other opportunistic Gram-negative bacteria, this pathogen establishes virulence and biofilms through lectin-mediated adhesion. Glycans and glycomimetics have become devices of choice to antagonize or disrupt such interactions. The article provides an overview of this topic, highlighting anti-microbial resistance (AMR), anti-adhesion therapy (AAT), carbohydrate-lectin interactions, and glycomimetics as therapeutic agents. An example highlights the case of MDR lung pathogens, in particular Burkholderia cenocepacia.


Latest news

The role of glycosaminoglycans (GAGs) in modulating bone morphogenetic protein (BMP) signaling is a relatively...

Glycans, due to their variable compositions and highly dynamic conformations, significantly enhance the diversity of...

Advances in simulation, combined with technological developments in high-performance computing, have made it possible to...

Antimicrobial resistance (AMR) is one of the most critical threats to global public health in...