Search
Close this search box.

Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies

Author(s)

F.A. Lempp, L. Soriaga, M. Montiel-Ruiz, F. Benigni, J. Noack, Y-J Park, S. Bianchi, A.C. Walls, J.E. Bowen, J. Zhou, H. Kaiser, A. Joshi, M. Agostini, M. Meury, E. Dellota Jr, S. Jaconi, E. Cameroni, J. Martinez-Picado, J. Vergara-Alert, N. Izquierdo-Useros, H.W. Virgin, A. Lanzavecchia, D. Veesler, L.Purcell, A. Telenti & D. Corti

Sources

Nature, 2021, 598, 342–347. https://doi.org/10.1038/s41586-021-03925-1

SARS-CoV-2 infection, involves cell attachment and membrane fusion and relies on the Angiotensin-converting enzyme (ACE2) receptor. This later is paradoxically found at low levels in the respiratory tract, suggesting that additional mechanisms facilitating infection may exist. The authors show that C-type lectin receptors, DC-SIGN, L-SIGN and the sialic acid-binding Ig-like lectin 1 (SIGLEC1) act as attachment receptors. They enhance ACE2-mediated infection and modulate the neutralizing activity of different classes of spike-specific antibodies. These findings identify a lectin-dependent pathway that enhances ACE2-dependent infection by SARS-CoV-2. They reveal distinct mechanisms of neutralization by different classes of spike-specific antibodies. One of these mechanisms possibly results in creating multinucleate viral factories, potentially enhanced by specific antibodies.

Latest news

The role of glycosaminoglycans (GAGs) in modulating bone morphogenetic protein (BMP) signaling is a relatively...

Glycans, due to their variable compositions and highly dynamic conformations, significantly enhance the diversity of...

Advances in simulation, combined with technological developments in high-performance computing, have made it possible to...

Antimicrobial resistance (AMR) is one of the most critical threats to global public health in...